BUSINESS

1. Contract research of protein crystallization in microgravity

Accelerating Structure-based Drug Development Through Space-based Protein Crystallization

Space LiinTech provides contract research services for protein crystallization under microgravity. This approach helps address gravity-related limitations observed on Earth, including convection, secondary nucleation, aggregation, and polymorphism. These factors can reduce crystal uniformity and size, which in turn can limit structural interpretability in drug development.

By leveraging microgravity conditions in space, we support the growth of larger and more uniform crystals, including targets that are difficult to crystallize on Earth. This can enable high-resolution structural analysis, including hydrogen-bond-level insights, and can accelerate structure-based drug discovery workflows.

2. Contract production of pharmaceuticals and APls using microgravity

Expanding Korea’s API Capabilities Through Space-based Manufacturing

Space LiinTech is developing microgravity-enabled production modules and contract-based manufacturing capabilities for pharmaceuticals and active pharmaceutical ingredients (APIs). This work supports Korea’s growing API ecosystem by exploring scalable production approaches in space.

Microgravity can offer physical advantages, including reduced shear stress and improved molecular diffusion. Building on these conditions, we aim to enable high-purity biologics and APIs, particularly for processes that are challenging to stabilize under Earth’s gravity. Our space production modules are designed with automation, real-time environmental monitoring, and advanced process control to support reliable biomanufacturing in orbit.

3. Research and Development of Cellular Therapeutics

Gravito-Electroporation: A Platform for High-Efficiency Gene Delivery

Space LiinTech is developing a gene delivery platform for cell therapies that combines electroporation with controlled gravity conditions. By operating under variable gravity, we aim to create a more uniform electroporation environment, improving gene transfer efficiency and post-transfection viability.

Our proprietary Gravito-Electroporation technology is designed to deliver genetic material across diverse cell types while minimizing cell stress and damage. This platform has the potential to enhance transfection performance for next-generation cell and gene therapies.

1. ISS-based Biopharma Research Platform

Protein Crystallization on the International Space Station

Space LiinTech provides standardized and customizable microgravity experiment modules under the BEE platform brand (Biomedical Extraterrestrial Enclosure), compatible with the ISS EXPRESS Rack, enabling reliable power, control, and data for biopharma research. Once installed and powered, our modules execute experiments autonomously with crew-minimal involvement, while real-time monitoring is enabled through onboard sensors and internal imaging.

Building on our ISS demonstration milestone, we demonstrated Korea’s first protein crystallization module on the ISS in August 2025. Our ISS module architecture started with a 2U form factor for space-ready integration. It is designed to scale to 4U and 6U configurations to support broader experimental needs.

2. Satellite-based Platform for Biopharma Research

Deploying LEO satellite modules for microgravity biopharma research

Space LiinTech develops and operates satellite-based modules in low Earth orbit (LEO) to enable microgravity biopharma research, including protein crystallization and bioproduction studies. These platforms are designed to support scalable in-orbit R&D and technology validation.

We work with domestic and international launch providers and in-orbit service partners to support payload integration, launch, and mission operations for our LEO platforms.

3. Ground-based Drop Tower Transfection Platform

Gravitational Biology Research Using Earth-Based Microgravity Analog Systems

Drop towers induce microgravity conditions (approx. 10⁻³ to 10⁻⁶ G) during brief periods of free fall, allowing essential biomedical experiments to be performed under near-weightless environments. Space LiinTech operates multiple drop tower facilities to support the development and validation of space biopharmaceutical technologies, particularly in the field of gene transfection.

Our facilities include:

Jeongseon Drop Tower: Developed in collaboration with the Institute for Basic Science (IBS), using a repurposed vertical mine shaft to generate controlled microgravity conditions.
Taebaek Drop Tower: A new 900-meter-class vertical shaft drop tower is under construction at the Jangseong Mining Complex in Taebaek.
Giheung Gravity Lab: Compact indoor drop towers are in active use for iterative testing and protocol validation.

Our drop tower systems enable scalable, customizable platforms for transfection research and simulation-based validation of microgravity applications on Earth.

Space LiinTech connects ground validation and in-orbit research for space-enabled biopharma R&D. We combine drop towers, ISS-compatible experiment modules, and LEO satellite platforms with end-to-end mission support. Our services cover microgravity protein crystallization, bioprocess studies, and transfection protocol validation.

Use cases

Structure-based drug discovery through microgravity protein crystallization
Bioprocess and manufacturing studies for APIs and biologics in microgravity
Transfection research and protocol validation using controlled gravity conditions

Contact us to discuss your experiment requirements and mission timeline.

Platform Infrastructure for Space Biopharmaceutics Innovation

Core Platforms for Space Biopharmaceutical Validation

BEE-PC1

BEE-1000

BEE-1012

How We Deliver Space Biopharma Validation