BUSINESS

1. Contract research of protein crystallization in microgravity

Accelerating Structure-Based Drug Development Through Space Bio Protein Crystallization

Protein crystallization on Earth faces limitations due to gravity-induced convection currents, leading to challenges such as secondary nucleation, crystal aggregation, and polymorphism. These factors restrict crystal uniformity and size, posing obstacles in structural analysis for drug development.

Crystallization in microgravity of space can leverage this situation. Near zero net gravity significantly minimizes gravitational effects, enabling the formation of larger and more uniform crystals. This advancement allows for difficult-to-crystallize proteins to be analyzed by crystallography, and even those that had previously been studied to be further analyzed to hydrogen-bond level.

Protein Crystallization in SpaceMicrogravity

2. Contract production of pharmaceuticals and API using microgravity

Joining South Korea’s Rapidly Growing API Production Industry Through Space-Based Pharmaceutical Manufacturing

Space LiinTech is advancing pharmaceutical and active pharmaceutical ingredient (API) production in space, contributing to South Korea’s rapidly expanding API manufacturing sector.

Utilizing the unique conditions of space, space-based API production techniques play a pivotal role in the advancement of pharmaceutical industrialization. By integrating essential technologies such as automation, environmental monitoring, and control within space modules, we are establishing a next-generation biologics production ecosystem.

3. Research and Development of Cellular Therapeutics

Advancing Gene Delivery for Cell Therapy Through Gravity-Based Innovation

Space LiinTech is developing a novel gene delivery method—a core technology for cell therapy development—by leveraging gravitational variations. Changes in gravity offer the advantage of applying uniform force across all samples, while also ensuring that cellular recovery occurs rapidly, leading to higher cell survival rates.

Our proprietary Gravito-Electroporation technology enables efficient gene transfer while maintaining high cell viability. This breakthrough is expected to be highly effective for transfection across a wide range of cell types, opening new possibilities for next-generation cell therapy applications.

1. Space Station based Research Platform

Drug Development Platform Utilizing Microgravity on the International Space Station (ISS)

Space LiinTech provides a drug development platform service for protein crystallization and organoid production under microgravity conditions on the International Space Station (ISS).

Through this space-based drug development platform, we aim to accelerate the development of immuno-oncology drugs, COVID-19 treatments, and other pharmaceuticals.

To achieve this, we are collaborating with launch vehicle companies in the United States and other global partners, with the goal of launching by June of 2025 and our commercial platform service beginning in 2027.

By leveraging the microgravity environment, this platform enables the precise growth of protein crystals, which is challenging to achieve on Earth. This advancement allows for accurate structural analysis, ultimately leading to reduced drug development time and costs.

Protein Crystal Growth in Capillary

2. Satellite-based research platform for pharmaceutical development

Developing and Operating a Low-Earth Orbit Platform for Advanced Space Biotechnology

Space LiinTech develops and operates platform solutions that provide low-Earth orbit satellite-based modules for protein crystallization, and bioproduction under microgravity conditions.

To achieve this, we are collaborating closely with various domestic and international launch vehicle companies and space station transportation providers, ensuring seamless integration and deployment of our cutting-edge space biotechnology solutions.

3. Transfection platform utilizing Drop tower
3.1 Research platform for Transfection
3.2 Microgravity analog test for space environment

In a drop tower, an experiment module undergoes free fall due to gravity, experiencing microgravity conditions (10⁻³ to 10⁻⁶ G) close to zero gravity (0G). Due to air resistance and other factors, complete weightlessness is not achieved, but the microgravity environment provided is crucial for testing and validating space biomedical research. During a brief free-fall period (less than 15 seconds), biochemical experiments can be conducted effectively.

Space LiinTech has established and operates drop towers utilizing vertical mine shafts in Gangwon Province, South Korea. The Jeongseon Drop Tower is developed in collaboration with the Institute for Basic Science (IBS) Underground Laboratory, while a 900-meter-long drop tower, the world’s longest, is currently under construction using the vertical shaft of the Jangseong Mining Complex in Taebaek.

Additionally, we have developed mini drop towers for indoor use, which are utilized for experiments and research at the Gravity Lab in Giheung. Moving forward, we will continue to develop and operate various types of drop towers tailored to specific research purposes and methodologies.

Leading the Future of Space Medicine Space LiinTech, a pioneering company in space medicine in South Korea, is building a pharmaceutical industry ecosystem based on space technology.

To achieve this, we are developing and operating platforms for low Earth orbit-based bio-research and space pharmaceutical production, as well as launch services. Additionally, we construct and manage drop towers, which simulate microgravity, hypergravity, and low-gravity conditions on Earth.

Through this innovative space pharmaceutical research and production system, which encompasses ground-based facilities, space stations, and satellites, we provide cutting-edge solutions, including:

•Structure-based drug discovery research using protein crystallization in microgravity

•Contract manufacturing of key substances in space conditions

•Cell therapy research solutions utilizing intracellular gene delivery techniques

Space LiinTech is committed to advancing space medicine and pharmaceutical technologies, bridging the gap between terrestrial and space-based healthcare innovations.

SLT Core capability and facility

SLT Core Platform

BEE-PC1
( Protein Crystallization )

BEE-1006

BEE-1012

BEE-FRM / FPM

BEE-1000 Space Environment Test (KTL)

Space LiinTech Business Model